Clinical Studies

Over 50 scientific publications have been published on Chemical Lipolysis, or Lipodissolve. Several are large scale and include double-blind studies. More than 100,000 treatments in total have been documented. The rate of more serious complications is 0.0017%. New research and publications are in process continuously.


New Evidence Validates ASAL Lipodissolve®

Recent clinical research by Division of Plastic Surgery, University Hospital of Regensburg, and the Clinical Research Center, Max Delbrück Center for Molecular Medicine in Germany, published in August 2009 verifies the effective reduction of fat with ASAL Lipodissolve. Additionally, a U.S. study was conducted by the Craniofacial Institute, Providence Hospital in Michigan confirming the same.

All three in-depth studies demonstrate clear clinical evidence that Chemical Lipolysis is an effective treatment for non-surgical fat reduction or lipolysis procedures. According to the studies >50% of the fat cells injected disappeared during 30 min incubation and nearly 100% fat cell lysis was observed after 24 h.

The original developers, ASAL, have a patent for the Lipodissolve formula.


2008-2009 Lipodissolve Summary
Issued for publication Complications of Lipodissolve: Investigating 11,651 Treatments
Euro Journal of Obesity
Obes Facts 2009;2:36-39
Compounds Used for ‘Injection Lipolysis’ Destroy Adipocytes and other Cells Found in Adipose Tissue
Plast Reconstr Surg. 2009 Aug;124(2):419-27 In vitro studies investigating the effect of subcutaneous phosphatidylcholine injections in the 3T3-L1 adipocyte model: lipolysis or lipid dissolution?
Aesthetic Plast Surg. 2009 May;33(3):346-52. Epub 2009 Feb 7. Actions and comparative efficacy of phosphatidylcholine formulation and isolated sodium deoxycholate for different cell types.
Clinics in Pl Surgery
Volume 36, Issue 2, Page 193 (April 2009)
Comment on “Mesotherapy and Injection Lipolysis”
Clinics in Pl Surgery
Volume 36, Issue 2, Pages 195-209 (April 2009)
Refinement of Technique in Injection Lipolysis Based on Scientific Studies and Clinical Evaluation
Clinics in Pl Surgery
Volume 36, Issue 2, Pages 211-213 (April 2009)
Comment on “Refinement of Technique in Injection Lipolysis Based on Scientific Studies and Clinical Evaluation”
Clinics in Pl Surgery
4/2009, Vol 36, Iss 2, Pg 215-221
The Lipodissolve Technique: Clinical Experience
Clinics in Pl Surgery
Volume 36, Issue 2, Pages 223-226 (April 2009)
Review of “The Lipodissolve Technique: Clinical Experience”
Clinics in Pl Surgery
Volume 36, Issue 2, Pages 181-192 (April 2009)
Mesotherapy and Injection Lipolysis
JDDG: Vol 6, issue 4, pages 287-290, April 2008 Injection lipolysis for reduction of saddlebag trochanteric bulges – half-side controlled pilot study [German]
Dermatol Surg
Phosphatidylcholine and Sodium Deoxycholate in the Treatment of Localized Fat: A Double-Blind, Randomized Study
Dermatol Surg
Tissue-Toxic Effects of Phosphatidylcholine/Deoxycholate after Subcutaneous Injection for Fat Dissolution in Rats and a Human Volunteer
Aesthetic Surg J 2006;26:575–585. Clinical Safety Data and Standards of Practice for Injection Lipolysis: A Retrospective Study
J Cutan Pathol
July 2007; 34; 7; 552-557
Fat tissue after lipolysis of lipomas: A histopathological and immunohistochemical study
J Cutan Med Surg 2006;10:155-159 Lipolysis of Lipomas in Patients with Familial Multiple Lipomatosis: An Ultrasonography-Controlled Trial
Aesthetic Pl Surg
Injection of Phosphatidylcholine in Fat Tissue: Experimental Study of Local Action in Rabbits
Aesthetic Surg J 2007;27:204–211 Detailed Documentation of One Lipolysis Treatment: Blood Values, Histology, and Ultrasound Findings
Aesthetic Surg J
Complications of Lipostabil Endovena for Treating Localized Fat Deposits
Aesthetic Surg J
Lipodissolve for Subcutaneous Fat Reduction and Skin Retraction
J Am Acad Dermatol
2005; 53; 973-8
Lipomas treated with subcutaneous deoxycholate injections
Arch Dermatol;
Vol 142; March 2005
Intralesional lipolysis with Phosphatidylcholine for the treatment of lipomas: pilot study
J Cosm Dermatol
2006; 5; 218–226
Clinical experience and safety using phosphatidylcholine injections for the localized reduction of subcutaneous fat: a multicentre, retrospective UK study
Indian J Plast Surg
July-December 2005;
Vol 38; Issue 2
Efficacy of injections of phosphatidylcholine into fat deposits—a non-surgical alternative to liposuction in bodycontouring
J Cosm Dermatol
2005; 4; 308–313
Phosphatidylcholine treatment to induce lipolysis
Aesth Plast Surg
2003; 27; 315-318
The use of Phosphatidylcholine for correction of localized fat deposits
TOXICOLOGY STUDIES The raw materials recommended for Lipodissolve injections are registered with an FDA Master File. The materials are supported by extensive research data and safety reports, including toxicology studies.
Bosn. J. Basic Med.
Sci. 5, 63-68.
Oral acute toxicity of polyenylphosphatidylcholine (PPL) in rats.
Liposome Technology, Vol. III, 2nd Edition, CRC Press, Boca Raton, Fl.; 1993. Tolerability of Liposomes in vivo.
Liposome Dermatics,
Springer Verlag, 1992
Toxicological and Enviromental Advantages
Artheriosclerosis. 16,
89-94. 1972
A Comparison of the Effects of Saturated and Polyunsaturated Lysolecithin Fractions on Platelet Aggregation and Erythrocyte Sedimentation.
Pharmacometrics. 3,
45-56. 1969
Acute and Subacute Toxicities of the Essential Phospholipids Injection.
  • American Society of Aesthetic Lipodissolve

  • American Society of Aesthetic Lipodissolve (ASAL, LLC) is the original founder and developer of the Chemical Lipolysis substance and treatment, previously known as ASAL Lipodissolve and Injection Lipolysis. The substance originates from 50 years of use in cardiology.

  • Clinical feedback from 67,000 patient treatments in the United States conclude risks to be less than 1%, and have been minor. Patient satisfaction on a scale of 0-100% from clinical feedback is an average 88%, higher than surgical liposuction.

    ASNA is the sole certified training provider for accurate Lipodissolve protocols in the United States.

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